Commentary: The ‘Runner’s High’ May Result from Molecules Called Cannabinoids – the Body’s Own Version of THC and CBD

Woman running on the road

Many people have experienced reductions in stress, pain and anxiety and sometimes even euphoria after exercise. What’s behind this so-called “runner’s high”? New research on the neuroscience of exercise may surprise you.

The “runner’s high” has long been attributed to endorphins. These are chemicals produced naturally in the body of humans and other animals after exercise and in response to pain or stress.

However, new research from my lab summarizes nearly two decades of work on this topic. We found that exercise reliably increases levels of the body’s endocannabinoids – which are molecules that work to maintain balance in the brain and body – a process called “homeostasis.” This natural chemical boost may better explain some of the beneficial effects of exercise on brain and body.

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Commentary: The Brain May Use a Ton of Energy Because It’s ‘Leaking’

Your brain may be leaking … energy, according to a new study that may explain why your noggin consumes 20% of the energy needed to keep your body running.

The study researchers found that tiny sacs called vesicles that hold messages being transmitted between brain cells may be constantly oozing energy, and that leakage is likely a trade-off for the brain being ready to fire at all times, according to a new study published Dec. 3 in the journal Science Advances. 

“The brain is considered a very expensive organ to run,” said senior author Timothy Ryan, a professor of biochemistry at Weill Cornell Medicine in New York City.

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